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Amitraz |
Chemical name: |
N'-(2,4-dimethylphenyl)-N-[[(2,4-dimethylphenyl)imino]methyl]-=N-methylmethanimidamide |
Molecular weight: |
293.4
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Molecular formular: |
C19H23N3 |
Mode of action: |
Non- systemic, with contact and respiratory action. Expellent action causes ticks to withdraw mouthparts rapidly and fall off the host animal. |
Uses: |
Control of all stages of tetranychid and eriophyid mites, pear suckers, scale insects, mealybugs, whitefly, aphids, and eggs and first instar larvae of Lepidoptera on pome fruit, citrus fruit, cotton, stone fruit, bush fruit, strawberries, hops, cucurbits, aubergines, capsicums, comatose, ornamentals, and some other crops. Also used as an animal ectoparasiticide to control ticks, mites and lice on cattle, dogs, goats, pigs and sheep. |
Physical chemistry: |
Form White/pale yellow crystalline solid. M.p. 86-88℃ V.p.<0.34 mPa (25℃) using clapeyron-clausius analysis Kowlogp=5.5(25℃, pH 5.8) Henry<1.0 Pa m3 mol-1 (measured) S.g./density 1.128 (20℃) Solubility In water <0.1 mg/l (20℃). Soluble in most organic solvents; in acetone, toluene, xylene>300 g/l. Stability Hydrolysis DT50(25℃) 2.1 h(pH 5), 22.1 h(pH 7), 25.5 h(pH 9). U.V. light appears to have little effect on stability. pKa 4.2, weak base
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Mammalian toxicology: |
Reviews FAO/WHO 83,85(see part 2 of the Bibliography) Oral Acute oral LD50 for rats 650, mice>1600 mg/kg. Skin and eye Acute percutaneous LD50 for rats>200,rats>1600 mg/kg. Inhalation LC50 (6 h) for rats>65 mg/l air. NOEL in 2 y feeding trials, no adverse effect observed in rats receiving 50-200 ppm diet, or in dogs dosed 0.25 mg/kg daily. Human NOEL>0.125 mg/kg daily. ADI (JMPR) 0.01 mg/kg b.w. [1998]. Toxicity class WHO(a.i.) lll; EPA (formulation) lll EC hazard Xn; R22
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Ecotoxicology: |
Birds LD50 for bobwhite quail 788 mg/kg. LC50 (8 d) for mallard ducks 7000, Japanese quail 1800 mg/kg. Fish LC50 (96 h) for rainbow trout 0.74m bluegill sunfish 0.45 mg/l. Due to rapid hydrolysis, it is unlikely that this toxicity will be expressed in natural aquatic systems. Daphnia LC50(48 h) 0.035 mg/l. Due to rapid hydrolysis, it is unlikely that this toxicity will be expressed in natural aquatic systems. Algae EC50 for Selenastrum capricornutum>12 mg/l. Bees Low toxicity to bees and predatory insects. LD50(contact) 50 ug/bee (formulation). Worms LC50 (14 d) for earthworms>1000 mg tech./kg. |
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